卡梅德生物科技（天津）有限公司

产品编号: KMP2246
产品名称: Human CD172a Protein, His Tag
中文名称: 重组人CD172a蛋白
中文全称: 重组人信号调节蛋白
关键词: 信号调节蛋白, Tyrosine-Protein Phosphatase Non-Receptor Type Substrate 1, SHP Substrate 1, SHPS-1, Brain Ig-Like Molecule with Tyrosine-based Activation Motifs, Bit, CD172 Antigen-Like Family Member A, Inhibitory Feceptor SHPS-1, Macrophage Fusion Receptor, MyD-1 Antige, Human CD172a Protein, His Tag, Recombinant Protein, KMP2246

物种: Human
宿主: HEK293 Cells
规格: 50ug, 100ug, 200ug
纯化方式: Affinity purification
纯度: >95% as determined by SDS-PAGE
内毒素水平: <1.0 EU/ug determined by the LAL method
缓冲体系: 20mM PB, 150mM NaCl, pH7.2
Uniprot: P78324
SDS-PAGE: KMP2246 SDS-PAGE image1.png
功能: Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity).
Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Plays a role in antiviral immunity and limits new world arenavirus infection by decreasing virus internalization (By similarity).
Receptor for THBS1 (PubMed:24511121).
Interaction with THBS1 stimulates phosphorylation of SIRPA (By similarity).
In response to THBS1, involved in ROS signaling in non-phagocytic cells, stimulating NADPH oxidase-derived ROS production (PubMed:24511121).
产品背景: Signal Regulatory Protein α(SIRPα) is a monomeric approximately 90 kD type I transmembrane glycoprotein. The 504 amino acid human SIRPα contains two Ig-like C1-type domains and one Ig-like V-type domain. SIRPα can express in various tissues, mainly on brain and myeloid cells, including macrophages, neutrophils, dendritic and Langerhans cells. It also can detect in neurons, smooth muscle and endothelial cells. SIRPA is an immunoglobulin-like cell surface receptor for CD47. SIRPα acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPα shows adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. SIRPα engagement generally produces a negative regulatory signal; it may mediate negative regulation of phagocytosis, mast cell activation and dendritic cell activation
保存条件: Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
运输条件: In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
说明: This product is for research use only.
官网链接: https://www.kmdbioscience.cn/
参考文献: 1.Curr. Biol. 9:927-930 (1999)                           
2.J. Immunol. 167:2547-2554 (2001)
3.J. Am. Soc. Nephrol. 25:1171-1186 (2014)